Research - More Information
Organic Photoreductants
For our halogen-bonding photocatalysis approach, we have developed Lewis base catalysts that directly engage with carbon–halide bonds via a halogen-bonding interaction, forming an electron donor-acceptor complex that can be activated by visible-light irradiation. Our second approach leverages simple 1,4-dihydropyridines anions as potent excited state photoreductants, enabling the reduction of a broad range of unactivated substrates under operationally simple and mild conditions.
Relevant Publications
Tarannum Tasnim, Calvin Ryan, Miranda L. Christensen, Christopher J. Fennell and Spencer P. Pitre*. Radical Perfluoroalkylation Enabled by a Catalytically Generated Halogen Bonding Complex and Visible Light Irradiation. Organic Letters 2022, 24, 446-450.
Prasadi G. Gallage, Mary G. McKee and Spencer P. Pitre*. 1,4-Dihydropyridine Anions as Potent Single-Electron Photoreductants. Organic Letters2024, 26, 1975-1979.
We would like to thank the following funding agencies for supporting this work:
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Nucleophilic Cobalt Catalysis
Relevant Publications
John Hayford G. Teye-Kau, Mayokun J. Ayodele and Spencer P. Pitre*. Vitamin B12-Photocatalyzed Cyclopropanation of Electron-Deficient Alkenes using Dischloromethane as a Methylene Source. Angewandte Chemie International Edition2024, 63, e202316064
We would like to thank the following funding agencies for supporting this work:
